Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D Study
Identifieur interne : 006051 ( Main/Exploration ); précédent : 006050; suivant : 006052Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D Study
Auteurs : K. Petoumenos [Australie] ; S. Worm [Danemark] ; P. Reiss [Pays-Bas] ; S. De Wit [Belgique] ; A. D Rminio Monforte [Italie] ; C. Sabin [Royaume-Uni] ; N. Friis-Moller [Danemark] ; R. Weber [Suisse] ; P. Mercie [France] ; C. Pradier [France] ; W. El-Sadr [États-Unis] ; O. Kirk [Danemark] ; J. Lundgren [Danemark] ; Mg Law [Australie]Source :
- HIV medicine [ 1464-2662 ] ; 2011.
Abstract
To estimate the rates of cardiovascular disease (CVD) events after stopping smoking in patients with HIV-infection.
Patients who reported smoking status, and no previous CVD prior to enrolment into D:A:D were included. Smoking status is collected at each visit as current smoker (yes/no) and ever smoker (yes/no). Duration since stopping smoking was calculated for persons who had reported current smoking during follow-up and no current smoking subsequently. Endpoints were: myocardial infarction (MI); coronary heart disease (CHD – MI plus invasive coronary artery procedure or death from other CHD); CVD (CVD – CHD plus carotid artery endarterectomy or stroke); and all-cause mortality.
Event rates were calculated for never, previous and current smokers, and smokers who stopped during follow-up. Incidence rate ratios (IRR) were determined using Poisson regression adjusted for age, sex, cohort, calendar year, family history of CVD, diabetes, lipids, blood pressure and antiretroviral treatment.
27,136 patients had smoking status reported, with a total of 432, 600, 746 and 1902 MI, CHD, CVD and mortality events respectively. The adjusted IRR of CVD in patients who stopped smoking during follow-up decreased from 2.32 within the first year of stopping to 1.49 after 3+ years compared to those who never smoked. Similar trends were observed for the MI and CHD endpoints. Reductions in risk were less pronounced for all cause mortality.
The risk of CVD events in HIV-positive patients decreased with increasing time since stopping smoking. Smoking cessation efforts should be a priority in the management of HIV positive patients.
Url:
DOI: 10.1111/j.1468-1293.2010.00901.x
PubMed: 21251183
PubMed Central: 3070963
Affiliations:
- Australie, Belgique, Danemark, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Aquitaine, Hovedstaden, Lombardie, Nouvelle-Aquitaine, Provence-Alpes-Côte d'Azur, Région de Bruxelles-Capitale, État de New York
- Bordeaux, Bruxelles, Copenhague, Milan, Nice
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Weber</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Mercie, P" sort="Mercie, P" uniqKey="Mercie P" first="P" last="Mercie">P. Mercie</name><affiliation wicri:level="3"><nlm:aff id="A8">INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2, Bordeaux, France; Hôpital Saint-André, Service de Médecine Interne, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2, Bordeaux, France; Hôpital Saint-André, Service de Médecine Interne, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Pradier, C" sort="Pradier, C" uniqKey="Pradier C" first="C" last="Pradier">C. Pradier</name><affiliation wicri:level="3"><nlm:aff id="A9">Nice Cohort, CHU Nice Hopital de l’Archet, Nice, France ; Nice University Hospital, Public Health, Rte Saint Antoine De Ginestiere, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Nice Cohort, CHU Nice Hopital de l’Archet, Nice, France ; Nice University Hospital, Public Health, Rte Saint Antoine De Ginestiere, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="El Sadr, W" sort="El Sadr, W" uniqKey="El Sadr W" first="W" last="El-Sadr">W. El-Sadr</name><affiliation wicri:level="2"><nlm:aff id="A10">Harlem Hospital and Columbia University, New York, NY, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harlem Hospital and Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kirk, O" sort="Kirk, O" uniqKey="Kirk O" first="O" last="Kirk">O. Kirk</name><affiliation wicri:level="3"><nlm:aff id="A2">Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Lundgren, J" sort="Lundgren, J" uniqKey="Lundgren J" first="J" last="Lundgren">J. Lundgren</name><affiliation wicri:level="3"><nlm:aff id="A11">Copenhagen HIV Programme (CHIP), Faculty of Health Sciences, The Panum Institute/Building 21.1, Copenhagen University, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen HIV Programme (CHIP), Faculty of Health Sciences, The Panum Institute/Building 21.1, Copenhagen University, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Law, Mg" sort="Law, Mg" uniqKey="Law M" first="Mg" last="Law">Mg Law</name><affiliation wicri:level="1"><nlm:aff id="A12">National Centre in HIV Epidemiology and Clinical Research, Biostatistics and Database Program, Darlinghurst, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre in HIV Epidemiology and Clinical Research, Biostatistics and Database Program, Darlinghurst, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21251183</idno><idno type="pmc">3070963</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070963</idno><idno type="RBID">PMC:3070963</idno><idno type="doi">10.1111/j.1468-1293.2010.00901.x</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001420</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001420</idno><idno type="wicri:Area/Pmc/Curation">001280</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001280</idno><idno type="wicri:Area/Pmc/Checkpoint">002187</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002187</idno><idno type="wicri:Area/Ncbi/Merge">000962</idno><idno type="wicri:Area/Ncbi/Curation">000962</idno><idno type="wicri:Area/Ncbi/Checkpoint">000962</idno><idno type="wicri:doubleKey">1464-2662:2011:Petoumenos K:rates:of:cardiovascular</idno><idno type="wicri:Area/Main/Merge">006388</idno><idno type="wicri:Area/Main/Curation">006051</idno><idno type="wicri:Area/Main/Exploration">006051</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Rates of cardiovascular disease following smoking cessation in patients with HIV infection: results from the D:A:D Study</title><author><name sortKey="Petoumenos, K" sort="Petoumenos, K" uniqKey="Petoumenos K" first="K" last="Petoumenos">K. Petoumenos</name><affiliation wicri:level="1"><nlm:aff id="A1">AHOD, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Coogee, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>AHOD, National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Coogee, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Worm, S" sort="Worm, S" uniqKey="Worm S" first="S" last="Worm">S. Worm</name><affiliation wicri:level="3"><nlm:aff id="A2">Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Reiss, P" sort="Reiss, P" uniqKey="Reiss P" first="P" last="Reiss">P. Reiss</name><affiliation wicri:level="1"><nlm:aff id="A3">ATHENA, HIV Monitoring Foundation, Academic Medical Center, Infectious Diseases, Amsterdam, AZ, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>ATHENA, HIV Monitoring Foundation, Academic Medical Center, Infectious Diseases, Amsterdam, AZ</wicri:regionArea><wicri:noRegion>AZ</wicri:noRegion></affiliation></author><author><name sortKey="De Wit, S" sort="De Wit, S" uniqKey="De Wit S" first="S" last="De Wit">S. De Wit</name><affiliation wicri:level="3"><nlm:aff id="A4">Saint-Pierre Cohort, CHU Saint-Pierre Hospital, Infectious diseases, Brussels, Belgium</nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea>Saint-Pierre Cohort, CHU Saint-Pierre Hospital, Infectious diseases, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="D Rminio Monforte, A" sort="D Rminio Monforte, A" uniqKey="D Rminio Monforte A" first="A" last="D Rminio Monforte">A. D Rminio Monforte</name><affiliation wicri:level="3"><nlm:aff id="A5">Hospital San Paolo, University of Milan, Clinic of Infectious Diseases, Medicine, Surgery and Dentistry, San Paolo, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Hospital San Paolo, University of Milan, Clinic of Infectious Diseases, Medicine, Surgery and Dentistry, San Paolo, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Sabin, C" sort="Sabin, C" uniqKey="Sabin C" first="C" last="Sabin">C. Sabin</name><affiliation wicri:level="2"><nlm:aff id="A6">UCL Medical School, Royal Free Campus, Primary Care and Population Sciences, London, England</nlm:aff><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>UCL Medical School, Royal Free Campus, Primary Care and Population Sciences, London</wicri:cityArea></affiliation></author><author><name sortKey="Friis Moller, N" sort="Friis Moller, N" uniqKey="Friis Moller N" first="N" last="Friis-Moller">N. Friis-Moller</name><affiliation wicri:level="3"><nlm:aff id="A2">Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Dep 044, Hvidovre University Hospital, Hvidovre, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Dep 044, Hvidovre University Hospital, Hvidovre</wicri:regionArea><wicri:noRegion>Hvidovre</wicri:noRegion></affiliation></author><author><name sortKey="Weber, R" sort="Weber, R" uniqKey="Weber R" first="R" last="Weber">R. Weber</name><affiliation wicri:level="1"><nlm:aff id="A7">Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland</nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea>Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Mercie, P" sort="Mercie, P" uniqKey="Mercie P" first="P" last="Mercie">P. Mercie</name><affiliation wicri:level="3"><nlm:aff id="A8">INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2, Bordeaux, France; Hôpital Saint-André, Service de Médecine Interne, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM E0338 & U593, ISPED, Université Victor Segalen Bordeaux 2, Bordeaux, France; Hôpital Saint-André, Service de Médecine Interne, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Pradier, C" sort="Pradier, C" uniqKey="Pradier C" first="C" last="Pradier">C. Pradier</name><affiliation wicri:level="3"><nlm:aff id="A9">Nice Cohort, CHU Nice Hopital de l’Archet, Nice, France ; Nice University Hospital, Public Health, Rte Saint Antoine De Ginestiere, Nice, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Nice Cohort, CHU Nice Hopital de l’Archet, Nice, France ; Nice University Hospital, Public Health, Rte Saint Antoine De Ginestiere, Nice</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Nice</settlement></placeName></affiliation></author><author><name sortKey="El Sadr, W" sort="El Sadr, W" uniqKey="El Sadr W" first="W" last="El-Sadr">W. El-Sadr</name><affiliation wicri:level="2"><nlm:aff id="A10">Harlem Hospital and Columbia University, New York, NY, United States</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harlem Hospital and Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Kirk, O" sort="Kirk, O" uniqKey="Kirk O" first="O" last="Kirk">O. Kirk</name><affiliation wicri:level="3"><nlm:aff id="A2">Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen HIV Programme (CHIP), Copenhagen University, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Lundgren, J" sort="Lundgren, J" uniqKey="Lundgren J" first="J" last="Lundgren">J. Lundgren</name><affiliation wicri:level="3"><nlm:aff id="A11">Copenhagen HIV Programme (CHIP), Faculty of Health Sciences, The Panum Institute/Building 21.1, Copenhagen University, Copenhagen, Denmark</nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea>Copenhagen HIV Programme (CHIP), Faculty of Health Sciences, The Panum Institute/Building 21.1, Copenhagen University, Copenhagen</wicri:regionArea><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Law, Mg" sort="Law, Mg" uniqKey="Law M" first="Mg" last="Law">Mg Law</name><affiliation wicri:level="1"><nlm:aff id="A12">National Centre in HIV Epidemiology and Clinical Research, Biostatistics and Database Program, Darlinghurst, NSW, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>National Centre in HIV Epidemiology and Clinical Research, Biostatistics and Database Program, Darlinghurst, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author></analytic><series><title level="j">HIV medicine</title><idno type="ISSN">1464-2662</idno><idno type="eISSN">1468-1293</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To estimate the rates of cardiovascular disease (CVD) events after stopping smoking in patients with HIV-infection.</p></sec><sec id="S2"><title>Design</title><p id="P2">Patients who reported smoking status, and no previous CVD prior to enrolment into D:A:D were included. Smoking status is collected at each visit as current smoker (yes/no) and ever smoker (yes/no). Duration since stopping smoking was calculated for persons who had reported current smoking during follow-up and no current smoking subsequently. Endpoints were: myocardial infarction (MI); coronary heart disease (CHD – MI plus invasive coronary artery procedure or death from other CHD); CVD (CVD – CHD plus carotid artery endarterectomy or stroke); and all-cause mortality.</p></sec><sec sec-type="methods" id="S3"><title>Methods</title><p id="P3">Event rates were calculated for never, previous and current smokers, and smokers who stopped during follow-up. Incidence rate ratios (IRR) were determined using Poisson regression adjusted for age, sex, cohort, calendar year, family history of CVD, diabetes, lipids, blood pressure and antiretroviral treatment.</p></sec><sec id="S4"><title>Results</title><p id="P4">27,136 patients had smoking status reported, with a total of 432, 600, 746 and 1902 MI, CHD, CVD and mortality events respectively. The adjusted IRR of CVD in patients who stopped smoking during follow-up decreased from 2.32 within the first year of stopping to 1.49 after 3+ years compared to those who never smoked. Similar trends were observed for the MI and CHD endpoints. Reductions in risk were less pronounced for all cause mortality.</p></sec><sec id="S5"><title>Conclusion</title><p id="P5">The risk of CVD events in HIV-positive patients decreased with increasing time since stopping smoking. Smoking cessation efforts should be a priority in the management of HIV positive patients.</p></sec></div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Danemark</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Hovedstaden</li><li>Lombardie</li><li>Nouvelle-Aquitaine</li><li>Provence-Alpes-Côte d'Azur</li><li>Région de Bruxelles-Capitale</li><li>État de New York</li></region><settlement><li>Bordeaux</li><li>Bruxelles</li><li>Copenhague</li><li>Milan</li><li>Nice</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Petoumenos, K" sort="Petoumenos, K" uniqKey="Petoumenos K" first="K" last="Petoumenos">K. Petoumenos</name></noRegion><name sortKey="Law, Mg" sort="Law, Mg" uniqKey="Law M" first="Mg" last="Law">Mg Law</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Worm, S" sort="Worm, S" uniqKey="Worm S" first="S" last="Worm">S. Worm</name></region><name sortKey="Friis Moller, N" sort="Friis Moller, N" uniqKey="Friis Moller N" first="N" last="Friis-Moller">N. Friis-Moller</name><name sortKey="Friis Moller, N" sort="Friis Moller, N" uniqKey="Friis Moller N" first="N" last="Friis-Moller">N. Friis-Moller</name><name sortKey="Kirk, O" sort="Kirk, O" uniqKey="Kirk O" first="O" last="Kirk">O. Kirk</name><name sortKey="Lundgren, J" sort="Lundgren, J" uniqKey="Lundgren J" first="J" last="Lundgren">J. Lundgren</name></country><country name="Pays-Bas"><noRegion><name sortKey="Reiss, P" sort="Reiss, P" uniqKey="Reiss P" first="P" last="Reiss">P. Reiss</name></noRegion></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="De Wit, S" sort="De Wit, S" uniqKey="De Wit S" first="S" last="De Wit">S. De Wit</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="D Rminio Monforte, A" sort="D Rminio Monforte, A" uniqKey="D Rminio Monforte A" first="A" last="D Rminio Monforte">A. D Rminio Monforte</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Sabin, C" sort="Sabin, C" uniqKey="Sabin C" first="C" last="Sabin">C. Sabin</name></region></country><country name="Suisse"><noRegion><name sortKey="Weber, R" sort="Weber, R" uniqKey="Weber R" first="R" last="Weber">R. Weber</name></noRegion></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Mercie, P" sort="Mercie, P" uniqKey="Mercie P" first="P" last="Mercie">P. Mercie</name></region><name sortKey="Pradier, C" sort="Pradier, C" uniqKey="Pradier C" first="C" last="Pradier">C. Pradier</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="El Sadr, W" sort="El Sadr, W" uniqKey="El Sadr W" first="W" last="El-Sadr">W. El-Sadr</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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